Tubular, Interstitial, and Cystic Diseases

These conditions often present with AKI, concentrating defects, electrolyte loss, flank symptoms, or imaging abnormalities rather than heavy glomerular proteinuria. Medication and exposure history is frequently decisive.

Start with three questions#

1. Does the pattern localise to tubules, interstitium, collecting system, or a structural lesion?
2. Which medications, toxins, infections, or hereditary clues are present?
3. What is reversible and what requires surveillance or specialist intervention?

How to use this section#

• Start with the presentation or clinical decision that brought the patient to nephrology.
• Use the topic pages for a concise differential, focused assessment, management principles, and escalation points.
• Confirm disease-specific treatment against the current linked guideline and local protocol before applying it in practice.

Editorial scope and review status

These pages are concise clinical drafts created from the original site structure. They are designed for clinician review and navigation, not as patient-specific treatment instructions. Recommendations, thresholds, drug choices, and local pathways should be checked during clinical review.

Reference framework#

• KDIGO — Acute Kidney Injury and Acute Kidney Disease
• KDIGO — Autosomal Dominant Polycystic Kidney Disease
• European Association of Urology — Urolithiasis