Knowledge section
Clinical Manifestations
Presentations that commonly lead to nephrology assessment, from urine abnormalities and fluid disorders to AKI, CKD, and nephritic or nephrotic syndromes.
Article contents · 3 sections
Use this section to start from the patient presentation. Each topic separates immediate threats from pattern recognition, focused testing, and the point at which a syndrome should be linked to a disease-specific page.
Start with three questions#
- Is there an immediate threat to life or kidney function?
- Is the pattern glomerular, tubular, vascular, obstructive, or systemic?
- Which findings require urgent nephrology or urology involvement?
How to use this section#
- Start with the presentation or clinical decision that brought the patient to nephrology.
- Use the topic pages for a concise differential, focused assessment, management principles, and escalation points.
- Confirm disease-specific treatment against the current linked guideline and local protocol before applying it in practice.
Editorial scope and review status
These pages are concise clinical drafts created from the original site structure. They are designed for clinician review and navigation, not as patient-specific treatment instructions. Recommendations, thresholds, drug choices, and local pathways should be checked during clinical review.
Reference framework#
Topics
Explore this section
Clinical Manifestations
Proteinuria
Classification, confirmation, differential diagnosis, and management principles for proteinuria and albuminuria.
Read topicClinical Manifestations
Hematuria
Evaluation, localisation, causes, and management of microscopic and visible haematuria.
Read topicClinical Manifestations
Polyuria
Evaluation of polyuria, water versus solute diuresis, and disorders of urinary concentration.
Read topicClinical Manifestations
Urinary Symptoms
A practical approach to urine colour, oliguria, nocturia, lower urinary tract symptoms, retention, and incontinence.
Read topicClinical Manifestations
Fluid Imbalance
Body fluid compartments, volume depletion, dehydration, and volume overload.
Read topicClinical Manifestations
Hypotension
Renal consequences, diagnostic approach, and management principles for acute and orthostatic hypotension.
Read topicClinical Manifestations
Edema
Mechanisms, differential diagnosis, volume assessment, and treatment of oedema.
Read topicClinical Manifestations
Nephrotic Syndrome
Recognition, complications, diagnostic work-up, and supportive management of nephrotic syndrome.
Read topicClinical Manifestations
Glomerulonephritis
Clinical recognition, classification, urgent work-up, and management principles for glomerulonephritis.
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Thrombotic Microangiopathy
Recognition and urgent differentiation of TTP, HUS, complement-mediated and secondary thrombotic microangiopathy.
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Acute Kidney Injury
Definition, phenotyping, investigation, immediate management, and follow-up of acute kidney injury.
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Chronic Kidney Disease
Definition, cause-GFR-albuminuria classification, risk assessment, and longitudinal management of CKD.
Read topicClinical Manifestations
Transition of Care for Young Adults
A structured approach to safe transition from paediatric to adult nephrology care.
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